All conditions
BPC-157 for ankle

Ligament Sprain

Of the 17 unique stories with a clear outcome, 12 reported it helped (71%). 3 were inconclusive.

These are public YouTube testimonials, not clinical evidence. People who tried BPC-157 and got no result rarely post videos — read this as a sample of the positive end of the distribution.

Verdict
71
% positive
11 helped1 partial5 no help3 unclear
What people tried
10mg, stomach and site injection, every night ×2injecting BPC-157, GHK-Cu, and thymosin, as well as using exosomes 250 micrograms sublingually once a day lyposomol 157
Source
Quote at 3:56
YouTubeHelped · completeinjecting BPC-157, GHK-Cu, and thymosin, as well as using exosomes
within 24 hours of my sprain I was back to walking 100% as if nothing had happened
Quote at 3:25
YouTubeHelped · significant250 micrograms sublingually once a dayover 8 weeks
my pain and stiffness in the knee significantly dropped
YouTube comment
@santafemyco5113
It healed me after a recent surgery. Recovered like a 20 year old. Took my attack Akita for a six mile morning walk 18 hours post surgery. Speaking of my Akita. She ripped ligaments attacking a pit bull, the pit bull growled. Thats all it takes to get an Akita into PROTECT MY OWNER MODE AND KILL. I immobilized her as much as possible during the one month treatment of the BPC-157. I made it easy on myself and found lyposomol 157, not the injection type. Her ligaments healed up faster than I’ve ever seen a human “heal” a ligament. I use to be a therapeutic massage therapists, I’ve literally had 2,500 clients at the spas, (now retired). I’m Very Familiar with the ligament injuries.
YouTube commentHelped · completelyposomol 157over 4 weeks
Her ligaments healed up faster than I’ve ever seen
@santafemyco5113·Youtube CommenterSource ↗
YouTube comment
@zachdancy5828
On bpc-157 currently for a torn mcl in my knee and lavator scapula between my scapula. Its been 1 week and no more constant nagging pain in both. I healed a torn rotator cuff in December 2022, which made me a massive believer! For martial arts and ballistic training, bpc-157 is a MUST!!
YouTube commentHelped · completeover 1 week
no more constant nagging pain
@zachdancy5828·Youtube CommenterSource ↗
YouTube comment
@williamC8227
I've taken bpc 157 orally for several months with really positive results as far as my digestion but it wasn't doing much for anything else. About 4 weeks ago while running I tore a ligament in the bottom of my left foot that was causing a lot of pain and discomfort while walking I wasn't able to run anymore. About a week ago I ordered a vial of BPC 157 mixed with tb500 and I started injecting it into my foot near where the pain was located and literally within 48 hours I'm able to walk on my foot comfortably again the pain has reduced significantly I had a feeling this stuff would work but I had no idea it would work that quickly my mind is blown away by it.
YouTube commentHelped · significantinjecting BPC 157 mixed with TB500 near the pain locationover 1 week
within 48 hours I'm able to walk on my foot comfortably again
@williamC8227·Youtube CommenterSource ↗
YouTube comment
@KetoMike59
Anecdotal.. Sprained wrist o.o.s. for 3 weeks. 4 days on the stack.. back in service .
YouTube commentHelped · complete4 days on the stackover 0.57 weeks
Sprained wrist o.o.s. for 3 weeks. 4 days on the stack.. back in service
@KetoMike59·Youtube CommenterSource ↗
YouTube comment
@macaw172
I seriously wounded my right foot in an accident in Iraq while in the army in 2007. several weeks ago i was chasing my nephews around in a trampoline park and torn a ligament in my right foot. BPC-157 healed my foot faster than what I thought was possible. I was also taking tesamorelin with my growth hormone so that could have played a part.
YouTube commentHelped · significant
BPC-157 healed my foot faster than what I thought was possible
@macaw172·Youtube CommenterSource ↗
YouTube comment
@punisher0717
I can tell you anecdotally IM bpc is far more effective. Even if it is just the antiflamatory properties I’ve noticed reduction in pain almost over night. Right next to the injection site will still be sore though. I sprained my ankle really bad, tore up a bunch of stuff. Now 5 months later I couldn’t understand why my knee was giving me problems, turns out in still dealing with an upper ankle sprain I didn’t even know about. I’m amazed how fast bpc157 works IM and in combination with igf1lr3 and mk677. I’m doing lots of heat, massage and stretching too. Along with some joint supplements and NAC
YouTube commentHelped · significantIM
reduction in pain almost over night
@punisher0717·Youtube CommenterSource ↗
r/Biohackers · Post
@DifficultReach2720
BPC-157 saved my foot
About 3 months ago I had a pretty bad ankle injury. Borderline torn ligaments and tendons in my ankle and foot. So I decided to start running BPC-157/TB-500 and honestly didn’t expect much beyond maybe helping a little. But now 3 months later it’s basically fully healed and feels great again. Could be coincidence, but the timeline felt way faster than any serious injury I’ve healed before. Now this could be placebo but I have also noticed, faster recovery between sets in the gym, less soreness day to day, and overall reduced inflammation. Ive been running about 300mcg’s of both daily for 3 months.
Reddit · r/BiohackersHelped · complete300mcg's of BPC-157 dailyover 12 weeks
it's basically fully healed and feels great again
@DifficultReach2720·Reddit UserSource ↗
r/Biohackers · Comment
@Acceptable_Taste9818
Ankle sprains are terrible. I just sprained mine lightly playing basketball yesterday. But I’m walking on it today with no bruising. My remedy is 9 hours of sleep every night until the soreness is gone😂. Typically works. Never had a sprain like your though.
Reddit comment · r/BiohackersHelped · significant9 hours of sleep every night
walking on it today with no bruising
@Acceptable_Taste9818·Reddit UserSource ↗
r/Biohackers · Comment
@heartbroken3333
Most people don’t want to inject anything. Diabetics inject insulin because it works. People on TRT often start with gels or creams, then switch to injections because they’re more consistent and effective. Not because they like needles. If you’ve had a knee ligament issue for years and you’ve already done PT multiple times, rested, strengthened, and modified everything you can, you’re not avoiding risk anymore. You’re just choosing the risk of staying the same. BPC-157 and TB-500 aren’t magic and they don’t have massive long term human data. That’s a fair concern. But they also aren’t random mystery drugs. There’s enough animal research and real world use that people with chronic connective tissue issues keep coming back to them for a reason. You can read up on Reddit on so many personal experiences about how effective BPC-157 and TB-500 worked for them. The injection part is mostly mental. Subq injections are shallow, clean, and controlled. Should be basically painless when done correctly but at worst, you feel a small poke (unless you hit scar tissue or something else). Once you learn to do it properly, it stops feeling “dirty” and just becomes another routine, like any other medical self care. The real question isn’t “are injections scary?” It’s how many more years you’re willing to deal with the same injury before trying something different. After a few injections, you'll realize how simple, easy, and effective it is and you'll probably always want to administer every drug possible through injections including benadryl but that's a different story. Within a few months, you'll be researching all these chemical compounds and wanting to inject a full catalog of them (at least for most people who are into biohacking their bodies).
Reddit comment · r/BiohackersHelped · significant
people with chronic connective tissue issues keep coming back to them for a reason
@heartbroken3333·Reddit UserSource ↗
YouTube comment
@truthbetold6496
I mix with dextrose for prolotherapy works fine, ligament instability cause by an idiot chiro russel oneill, squat deadlift must be avoided, i got PRP and prolo back to power lifting and re injured myself also 2 weeks sorry no way, i been on for 1 month and just barely feeling better its around 3 month mark
YouTube commentHelped partially · mildmix with dextrose for prolotherapyover 4 weeks
i been on for 1 month and just barely feeling better
@truthbetold6496·Youtube CommenterSource ↗
YouTube comment
@DannyWilson-cy1to
Gday mate. I have an MCL tare in my right knee. How often should I inject bpc 157. Injury is 3 months old. Also should I take anything else with it.
YouTube commentInconclusiveover 12 weeks
I have an MCL tare in my right knee
@DannyWilson-cy1to·Youtube CommenterSource ↗
YouTube comment
@WheresNaldo
I just sprained my ankle really bad playing basketball. I already had TB-500 and PBC-157 as I was planning on taking it to heal my kidneys. Let’s see how long it takes my ankle to heal. I’m starting on Monday after I get my blood drawn.
YouTube commentInconclusive
I just sprained my ankle really bad
@WheresNaldo·Youtube CommenterSource ↗
r/Biohackers · Comment
@Zealousideal-Till879
Is there any evidence pointing to “more is better” with BPC, optimal dosing, or even the need for daily dosing? It’s got a super short half life but I understand it exerts effects for days and weeks after administration. I’m new to this and am suffering a serious ligament injury
Reddit comment · r/BiohackersInconclusive
suffering a serious ligament injury
@Zealousideal-Till879·Reddit UserSource ↗
YouTube comment
@Bfloian62
I have a few injuries .. torn ligament in my right wrist, torn muscle in left shoulder mild meniscus tear in my right knee and sprained hip flexer.. I’m 43 and have been injecting stomach are and site injection of bpc -157 and tb500 Wolverine stack two weeks ago every night. Out of 2x 10mg bottles I have about a half bottle left. I got them from core peptides but I don’t think they’re effective. I don’t feel any healing or slight improvement. Any thoughts? And recommended suppliers?
YouTube commentDidn't help10mg, stomach and site injection, every nightover 2 weeks
I don't feel any healing or slight improvement
@Bfloian62·Youtube CommenterSource ↗
YouTube comment
@Bfloian62
I have a few injuries .. torn ligament in my right wrist, torn muscle in left shoulder mild meniscus tear in my right knee and sprained hip flexer.. I’m 43 and have been injecting stomach are and site injection of bpc -157 and tb500 Wolverine stack two weeks ago every night. Out of 2x 10mg bottles I have about a half bottle left. I got them from core peptides but I don’t think they’re effective. I don’t feel any healing or slight improvement. Any thoughts? And recommended suppliers?
YouTube commentDidn't help10mg, stomach and site injection, every nightover 2 weeks
I don't feel any healing or slight improvement
@Bfloian62·Youtube CommenterSource ↗
YouTube comment
@vankuscarce5496
Doesn't angiogenesis stimulate cancer cells as well, my orthopedic said about a guy that used BPC-157 TB-500 and Growth Hormone and he indeed fixed his injuries very fast but got testicular cancer... Now I'm afraid to try BPC-157 and TB-500 together to fix my shoulder ligament injury
YouTube commentDidn't help
Now I'm afraid to try BPC-157 and TB-500 together to fix my shoulder ligament injury
@vankuscarce5496·Youtube CommenterSource ↗
r/Biohackers · Post
@Mean-Chipmunk1023
BPC 157
I was wondering if anyone could try to convince me that injecting this stuff is safe and easy. Ive had knee ligament issues for years after a bad hyperextension injury and have gone through the PT regime several times. I heard a little bit about BPC 157 and TB500 but I can't seem to get over the injecting part, it just feels dirty. Any advice or thought from others that have gone a similar route would be appreciated!
Reddit · r/BiohackersDidn't help
knee ligament issues for years after a bad hyperextension injury
@Mean-Chipmunk1023·Reddit UserSource ↗
r/Biohackers · Post
@filthy_casual240
BPC 157 While on accutane?
Ive been on accutane for about 2 months, now on 60mg a day, i have no major muscle pain or joint pain but a minor LCL injury i picked up from BJJ came back when i started 60mg it refuses to go away and rehab isnt helping at all. has anyone got any experience using BPC 157 while on accutane or any advice to why it might be/not be worth it?
Reddit · r/BiohackersDidn't help
refuses to go away and rehab isnt helping at all
@filthy_casual240·Reddit UserSource ↗
What the science says

Related research

All papers →
Review· ratmedium
2026

Tendon, Ligament, and Muscle Injury, Osteotendinous, Myotendinous, and Muscle-to-Bone Junction Therapy Perspectives with Growth Factors and Stable Gastric Pentadecapeptide BPC 157-A Review.

This review concludes that BPC 157, a stable gastric pentadecapeptide, shows promise in treating complex musculoskeletal and junctional injuries, with efficacy in tendon, ligament, and muscle healing. BPC 157 appears to have a full cytoprotection range and can be administered systemically or locally without a carrier.

Pharmaceuticals (Basel, Switzerland)· Matek D, Matek I et al.
PubMed · PMID 41754849
Animal study· ratmedium
2010

Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat.

The peptide BPC-157 improved healing of medial collateral ligament injuries in rats when given intraperitoneally, locally, or per-orally. The treatment resulted in consistent functional, biomechanical, macroscopic, and histological healing improvements.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society· Cerovecki T, Bojanic I et al.
PubMed · PMID 20225319
Review· nulllow
2025

Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review.

This systematic review suggests that BPC-157 shows promise for promoting recovery from musculoskeletal injuries, with preclinical studies showing improved functional, structural, and biomechanical outcomes in muscle, tendon, ligament, and bony injuries. However, the review highlights the need for further clinical safety data and notes that adverse effects are possible due to unregulated manufacturing or contamination.

HSS journal : the musculoskeletal journal of Hospital for Special Surgery· Vasireddi N, Hahamyan H et al.
PubMed · PMID 40756949
Review· mouselow
2019

Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing.

This review concludes that BPC-157 has shown consistently positive and prompt healing effects for various soft tissue injuries in animal models, but its efficacy in humans is yet to be confirmed. The peptide has potential as a therapy for conservatively treating or aiding recovery in hypovascular and hypocellular soft tissues.

Cell and tissue research· Gwyer D, Wragg NM et al.
PubMed · PMID 30915550