Peptide Masterclass: Correcting The Gut With BPC-157

let's talk about correcting the gut for good because a lot of people ask me well should I be taking probiotics what about prebiotics and how can I constantly renew my gut and what probiotics should I be taking and I think that world can get super complicated and and you can end up taking so many different probiotics and and you know we actually there's a research that we did out of my school well one of the research projects we did was on Prozac I don't know if I've ever talked to you about this but we we tested Prozac versus placebo and the the patients who took the placebo actually had a better outcome and that you know that was interesting but the other one we did was we we in our lab we tested what was in probiotics and a lot of what we we found that were was on the label was not what was in the capsule and some of these some of the species and the phylum that we found in in in those probiotics were very pathogenic and so so with that how would you correct the gut for good and what would be some of your recommendations as far as pre and probiotics well I mean you know like the the acromantia but you know diversity you know I really try to go for diversity um I like uh saccharomyces boulardii yeah ain't that beneficial yeast in there um I use a lot of like bacillus subtilis and bacillus coagulants because they're like an antibiotic probiotic so those are super powerful as far as building that up and then you know I like to really reintroduce the short chain fatty acids like uh butyrate acetate propionate but specifically that butyrate and you know what's interesting is butyrate is like if you look at what butyrate does in the gut and you look at ll37 they're so they they correlate so well and you find butyrate stimulates ll37 production so it makes sense yeah so it makes sense that you know you have a gut that's really bad why ll37 you know instead of having to wait till you you know heal the gut and reintroduce all these healthy species and wipe out these microbes that you actually get you know ll37 on their protocol you know fascinating and I actually I didn't know that was a big uh secret to him of ll37 it makes sense because the the butyrate's right there on the intestinal lining and that's ll37 just hanging out on those epithelial cells just like waiting until it needs to be called into action so uh fascinating the and and uh one of the things that um I like about acromantia is it seems to have some very powerful blood sugar regulation impact and it builds up that mucosal lining on the inside of the gut and so I look at it as a way of building up the barrier and as far as all the probiotics that we've used um and yes you I wouldn't want someone to stay on acromantia long term every probiotic I say cycle on every two months and cycle off of it get on a different one so and I love the saccharomyces boulardii too because a lot of us we forget that your entire biome is more than just bacteria in your gut there's really healthy fungi and uh we always think that yeast is a bad thing but it actually is really good if you think about what cleans the environment it's the it's the mycelium it's the mushrooms that are hanging out there and they they uh they have their own orchestra going on beneath the soil it's pretty powerful if you if you've seen paul stamets uh video did you see that the magical mushroom video or I can't remember exactly what it's called that documentary on mushrooms that paul stamets did I always saw a short a really short version of it I didn't see the whole thing all right well you you got the gist of it then but yeah pretty fascinating so think about that in your gut as well and then for resistant starches one of the easiest things that you can do and have your patients do is have some cold potatoes I'm from Idaho and so I'm like potatoes have gotten a bad rap and everyone's like oh they make you fat and they're you know they're nightshades and so they're going to cause inflammation but I think we've been eating them the wrong way and so um all you need to do is every every week do some meal planning make your meat make your carbs and then cool them off and uh one of the the best ways you can get some nice prebiotics is take some sweet potatoes or russet potatoes whatever you like and then every morning when you break your fast that's what breakfast means You break the fast, slice off a little piece of that potato and eat it. And that's a great way of inoculating the gut and feeding the good bacteria, because really it's it's not always about putting more of a good thing in. It can also be about feeding what's already there. And I find that can be a really powerful habit to get into. And then, oh, it's called Shawnee. Thank you. It's called fantastic fungi. Yeah, it's not magical fungi, but fantastic fungi on Netflix. These these prebiotics. Yes, we love the carbohydrates and we get a little endorphin rush from them. But if you eat them later on in the evening and when you're more insulin sensitive, you'll have a much better outcome from them. But then if you can eat the right kind of carbohydrates, you can be really healthy for your gut. So let's jump into BPC 157, the body protective complex. Now, the way that this used to be made by pharmacies was through human gastric secretion. So all of these peptides, Hepatalin, LL37, KPV, these are all endogenously created. Like, I mean, these are in your body and their natural secret homes. And and remember, we're just turning up the orchestra. So these are the secret homes that seem to help us heal. So and what BPC has been shown to do is be protective with the gut barriers. It combats inflammation. It resolves IBS. One of the studies is and this is a study on rats. So I know I've been kind of going through Dan's favorite animals. But this gives Dan some hope that if your rat, Dan, ever happens to get tubal ligation in the hepatic portal vein, if someone ever happens to sniff that vein just on accident or if they're climbing over a barbed wire fence and it catches it, there's actually hope with BPC 157. Because in the research, they took these rats and researchers severed the hepatic portal vein and then they gave one group of rats just water to drink as they went jaundice and they went into liver failure and as they, you know, had a painful death. And the other group got BPC 157 in their water and similar to the experiment that was done with ulcerative colitis in mice with KPV, the BPC 157 is something that can be tolerated orally because it is a gastric secretion. And what happened to these rats is the the hepatic portal vein actually healed. Knowing all the mechanisms and the effect that BPC has on connective tissue, you know, it's going to have a, you know, a really powerful effect on that. And then, you know, just like you have on the barriers here, we know that it improves the nitric oxide pathways. But it's going to, you know, a lot's going to have to do with the connective tissues and having to do with the basement membrane of all of our endothelial tissue. Now, BPC is, as far as treatments go, it's known as the Wolverine peptide. It's one of those peptides you can use BPC with thymosin beta 4. If someone really has some massive dysregulation in their HPA axis, you know, like they can't sleep, they have gut issues, they're chronically stressed, they're just ruminating all the time. Then you can use BPC, thymosin beta 4, and epitalin. And you will see where someone's just about ready to be put on like Seroquel or, you know, some antipsychotic drugs, high-dose lithium, for example. This resets them. And then that whole psychosis mellows out. It's just a phenomenal thing. I've seen it in three different patients where it was tenuous at best in what they were dealing with. So pretty phenomenal there with BPC. Any other insights on BPC? You know, BPC, one of the reasons we love it so much is because it has a gabanergic response. So it has that inhibitory neurotransmitter pathway. And so, you know, with the gut, when we have these really disrupted guts, their neurotransmitters are so disruptive, get a lot of anxiety, depression along with that. We've seen some really good results. It totally changes certain people's behaviors like some of our IBS, IBD, ulcerative colitis patients. And here recently we have a guy who's, he's in stage four liver failure due to sclerosis and some necrosis. And there's research that shows that it is hepatoprotective against, you know, also, you know, from the NSAIDs, but also necrosis. you know, any type of necrotic or fatty liver accumulation. So I'll let you know how that goes. We just got him started on it. So. Okay. Beautiful. Yeah. Phenomenal peptide. So BPC is well tolerated by almost everybody we've used it on. We've never had any complications with it. Hey everybody, Reagan Archibald here. I hope you enjoyed the Go Wellness show and maybe learned a couple of things you could apply to your practice. 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